Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
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چکیده
منابع مشابه
Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats
OBJECTIVE The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in ...
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Doxorubicin is the mainstay of treatment for various haematological malignancies and solid tumours. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanism of doxorubicin-induced cardiotoxicity may involve various signalling pathways including free radical generation, peroxynitrite formation, calcium overloading, mitochondrial dysfunction and alteration...
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Purpose: The aim of the present study was to determine the ability of grape seed extract (GSE) as a powerful antioxidant in preventing adverse effect of doxorubicin (DOX) on heart function. Methods: Male rats were divided into three groups: control, DOX (2 mg/kg/48h, for 12 days) and GSE (100 mg/kg/24h, for 16 days) plus DOX. Left ventricular (LV) function and hemodynamic parameters were assess...
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We examined whether Crataegus aronia (C. aronia) can ameliorate Doxirubicin (DOX) induced cardiotoxicity in rats. Six groups of Wistar rats were divided as: Group I: a control group (administered saline); Group II: administered aqueous extract of C. aronia alone; Group III: administered DOX alone; Group IV: administered concomitant doses of both DOX and C. aronia; Group V: administered DOX firs...
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The present study was undertaken to explore the cardioprotective potential of bioflavonoids against isoproterenol induced cardiotoxicity in rats. Cardiotoxicity was induced by isoproterenol (85mg/kg body weight) in animals. Blood biochemical, hematological parameters, urinalysis and histopathological studies were carried to assess the cardio protective effect. Isoproterenol administration induc...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-71827-9